Thrombocytopenia is often divided into three major causes of low platelets: Low production of platelets in the bone marrow Increased breakdown of platelets in the bloodstream (called intravascular) Increased breakdown of platelets in the sp
Abnormal reductions in the number of platelets are caused when abnormalities occur in any of the following three processes: decreased platelet production by the bone marrow; increased trapping of platelets by the spleen; or a more rapid tha… Source:http://www.answerbag.com/q_view/465301
Thrombocytopenia? I don’t know if anyone knows what that is, but I figured I would ask anyways. Anyone know, heard or experienced it..Something like neoatal alloimmune thromb
Causes of Canine Idiopathic ThrombocytopeniaNumerous conditions may cause acquired thrombocytopenia including whole-body irradiation; drugs (levamisole, sulfonamide, antibiotics); toxins; viral, rickettsial or protozoan infections; chronic hepatitis; myelogenous leukemia; tumors (hemangiosarcoma); Addisons disease; vitamin B12 or folate deficiencies; severe iron deficiency or immune-mediated disorders! Overdose of intravenous heparin may induce severe thrombocytopenia in cats! Increased platelet destruction commonly results from overly-active macrophage system or immune-mediated mechanisms! Immune-mediated thrombocytopenia (ITP) is one of the most common causes of thrombocytopenia in dogs where the dogs immune system produces antibodies which attack and destroy the blood cells!Hereditary disorders causing thrombocytopenia are the Wiskott-Aldrich syndrome, a severe immunodeficiency disease characterized eczema!The most common infectious cause of thrombocytopenia in dogs is ehrlichiosis Infection with Ehrlichia canis and, less commonly, with E! platysand E! ewingii cause thrombocytopenia! Other infections causing thrombocytopenia include infectious canine hepatitis virus, distemper vaccination, peritonitis, dapsone therapy, myasthenia gravis, immune-mediated hemolytic anemia (IMHA) (the ITP and IMHA may occur simultaneously)! Drug sensitivity leading to thrombocytopenia may develop within a few days of initiation of drug therapy! Discontinuance of the offending drug is rapidly accompanied with return to the normal platelet levels!Thrombocytopenia in animals is also often associated with DIC, a disorder when the dogs blood clotting mechanisms are activated throughout the body instead of being localized to an area of injury! As a result, the blood clotting factors (proteins) are used up to such a degree that they not available to form clots at sites of real tissue injury!Severe bleeding, whether acute or chronic, is unlikely to cause thrombocytopenia because of the extra platelets stored in the spleen and other sites!Females and small breeds of dogs, such as Cocker Spaniels, appear predisposed to immune-mediated thrombocytopenia, and the cause of this condition remains unknown! Most affected dogs are middle-aged females or spayed females!
What is the cause of thrombocytopenia? When abnormalities occur in any of the following three processes: decreased platelet production by the bone marrow;
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